Dissecting that Neanderthal brain organoids Science pub

Organoids and especially brain organoids, which are made from pluripotent stem cells, are one of the most interesting developmental biology technologies of the last half a dozen or so years. Still some folks can’t help but get carried away when thinking about brain organoids it seems. A new Science paper …

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Recommended reads: pluripotent stem cells, neural crest, cancer, more

There has been quite a lot of pubs on research on pluripotent stem cells published lately. These include some more surprising findings such as a potential role for pluripotency-related programming in neural crest development. Pluripotency factors involved in early neural crest cell lineage development. “RNA FISH analysis of Oct4 and …

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Resolving the full structure of LRRK2 with cryo-ET

Up until now the structure of leucine-rich repeat kinase 2 or LRRK2 was not yet fully resolved. The paper Watanabe et al. that we discuss in this post explains how using fluorescent light microscopy (FLM), in situ cryo-electron tomography (cryo-ET) and subtomogram averaging analysis reveals the full structure of the …

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How Do They Work and How Do We Study Them?

This article was written by Alyssa Cecchetelli and Andrew Hempstead. What do smell, taste and sight have in common, besides being one of the five senses? GPCRs or G-protein-coupled receptors (GPCRs)! Aside from these three senses, GPCRs play roles in initiating signaling pathways in inflammation, and neurotransmission. These receptors can …

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Fact-check: F grade for irresponsible stem cell COVID-19 cure piece

At times there’s been seriously bad journalism covering COVID-19 itself including implications of various things being a COVID cure. Of course, media coverage of stem cell research itself sometimes ends up being a train-wreck of hype too. More recently we’ve seen irresponsible journalism also around the specific idea of stem …

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