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CRISPR critters advancing science & agriculture

CRISPR applications in the real world Author Mina Kim, intern on The Niche Blog. The “breakthrough” gene-editing tool, CRISPR Cas9, has been utilized for various purposes since its popularization and commercialization in the early 2010s. While possible uses of gene editing in humans tend to get the most attention, the …

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Studying UV LED materials with cathodoluminescence imaging

There is a growing number of applications in which LEDs are used (displays, ambient/car lighting, remote controls, optical switches to name a few). One of the most important components in an LED is the semiconductor chip from the light is emitted.  As such careful investigation of these semiconductor materials is …

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Regenerative reads: pig fat, cancer, organoids, more

It’s usually a tossup as to whether my weekly reads skew more towards stem cells/regenerative medicine or cancer. Other times they are more enriched for genomics and epigenetics articles. Pig fat for bone regenerative medicine (A) Representative Masson’s trichrome staining in sagittal subchondral cross sections of acellular, BO, CB, and …

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imaging large data in limited time

Recent years have seen a rapid increase in the field of connectomics, the study of tracing and understanding connectivity maps of the brain. Thanks to its ability to resolve the level of detail required to create these maps, electron microscopy has become an essential tool for the mapping efforts undertaken …

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Cathodoluminescence imaging for semiconductors

It is used to probe important material properties such as the local band edge emission, local defect band emission, point defects and delocalised defects. It also allows measuring damage and strain to the material, dopant distribution and carrier diffusion. These characteristics of semiconductor materials are very important for industrial applications. 

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Hot Plasmids – October 2020

Every few months we highlight a subset of the new plasmids and viral preps in the repository through our hot plasmids articles. These articles provide brief summaries of recent plasmid deposits and we hope they’ll make it easier for you to find and use the plasmids you need. If you’d ever …

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Subtomogram averaging in the cryo-ET workflow

This results in a high resolution 3D structure of a protein complex in its near-native confirmation. Depending on the quality of the reconstruction, subtomogram averaging can yield structures with near-atomic resolution. The quality of the reconstruction is dependent on nearly all steps in the workflow. Here we will highlight some …

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Weekly reads on organoids, COVID, CRISPR, cold chromatin, more

As a researcher, is there ever enough time to get to everything that you want to read especially in newer areas like stem cells, organoids, and CRISPR, without even including non-scientific reads like Shakespeare or a new novel or something like that? Hopefully, putting together lists of recommended reads like …

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