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Stem cells seed a new thymus, clinical hope?

Imagine receiving a smidgeon of thymus gland along with a donated heart or kidney, to fool the immune system into accepting the transplant. Authors of a new study argue that might be possible, based on their new proof-of-principle experiments. The team from the Epithelial Stem Cell Biology and Regenerative Medicine …

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Spicy stem cell pathways & other recommended reads

The stem cell paper of the week is a fun one about how capsaicin and nociceptors reportedly mobilize blood stem cells.  However, since the authors only show this in mice, could it also happen in humans? They argue it’s likely happening in people too. Note that nociceptors are special structures …

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What are totipotent stem cells & what can they do?

Sometimes patients or my students ask me, “What are the best stem cells?” what information are they looking for? I think they often are looking for the most powerful stem cells so perhaps they should be asking, “What are totipotent stem cells?” Other times it seems what patients specifically want …

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Cryo-ET imaging of SARS-CoV-2 replication organelles

Two interesting research papers that described the replication environment of SARS-CoV-2 will be discussed in this post. Both papers used cryo-ET and subtomogram averaging to image important molecules and structures that play a crucial role in the replication of the coronavirus genome.

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The Twelve Days of CRISPR

🎶 On the 12 days of CRISPR, Addgene gave to me… 🎶 A few years ago we used the #12DaysOfCRIPSR hashtag to share new CRISPR content designed to help you with your CRISPR experiments and to learn about new CRISPR tools. Since the CRISPR field keeps changing, we’ve been updating …

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Prop 14 California: Big Expectations for CIRM 3.0

Approval of Prop 14 California last month to renew CIRM was one of the biggest state election developments of 2020. Yet it didn’t get much news coverage somehow. The exception is David Jensen over at California Stem Cell Report, who has been a great source of information about the various …

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An “elegans” Approach to Better CRISPR/Cas9 Editing Efficiency

Originally published Jan 27, 2015 and last updated Dec 17, 2020. This post was contributed by Jordan Ward who is an assistant professor at the University of California, Santa Cruz. Emerging CRISPR/Cas9 editing technologies have transformed the palette of experiments possible in a wide range of organisms and cell lines. In C. …

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What is the newest application of cathodoluminescence imaging?

There is a lot of interest in the field of polymers and plastics due to their importance in environmental studies. Raman spectroscopy is currently one of the main techniques used to characterize these materials. While this yields valuable information, it is a slow and expensive technique. Moreover, there are serious …

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